Dan Yoder and wife Caroline are happily anticipating an empty nest as their daughter Molly gets ready to head off to college. Molly has some interesting news for them, however, and when she announces that she and her secret boyfriend Junior Hernandez are going to have a baby, they have to adjust to a new reality and meet their new family – Miguel and Lisette. When these two very different families are thrown together, it’s obvious that Dan and Miguel have the most difficult time adjusting to their new situation, while Caroline and Lisette take a softer approach.

Caroline heads to the doctor to confirm her suspicions but when she encounters Molly and Junior in the same waiting room, things get a little awkward. Then, as Joseph decides to invite his parents to the first sonogram, things get even more awkward. When Caroline later learns she is indeed pregnant, she struggles with the best way to break the news to Dan, who has been happily anticipating an empty nest. Meanwhile, Dan returns to Miguel’s boxing gym to get back into shape, and it doesn’t go well.

In a moment of wistfulness about his long lost freedom, Dan decides to purchase an RV for a little recreational family time. Caroline is not completely thrilled about the purchase and is most concerned about finding relief for her mounting nausea and intense appetite. Miguel and Lisette attend Demetrio’s Back to School Night and meet Demetrio’s sixth grade teacher Ana Nunez – who turns out to be an old flame of Miguel’s. Lisette, who is already feeling awkward about becoming a grandmother, is not happy to meet the gorgeous Ana. Meanwhile, Molly looks to her mother for advice on why Junior may be feeling less romantic now that she’s pregnant.

After landing a big client, Caroline eyes a promotion at work, but struggles to keep the pregnancy a secret until she can lock it in. Dan encourages Junior to lighten up a bit and have some fun so he considers rushing a fraternity on campus, which turns out to be Dan's old house. When Junior and Molly attend the Halloween costume party however, it becomes apparent that something has changed in the years since Dan was at school. Meanwhile, the Yoders entertain the Hernandez family for some Halloween trick-or-treating.

When Dan is short a player in his weekly basketball game, he invites Miguel to join but when Dan accidentally elbows Miguel in the mouth, the game goes from bad to worse. During the game, Lisette offers to take Caroline to her favorite Mexican restaurant for an amazing burrito but the ladies realize that they have differing opinions about the family drama surrounding them. Meanwhile, Molly is horrified to learn that the lab where Junior works is using animals for testing and it comes between them.

A visit by Lisette’s grandmother Lita, draws Molly and Caroline into a Hernandez family web of lies, including the old woman’s belief that Miguel is a lawyer.