Just another day in the office as The Toe Bro sees a former ballet dancer who longs to rid herself of painful ingrown toenails so she can dance again, a diabetic patient that takes back his mobility by having The Toe Bro battle his extreme pincer toenails, and a patient wants to make cracked heels a thing of the past so she can wear those hot new shoes to girls' night out. None of this could prepare The Toe Bro for the Toezilla, a huge big toe ballooning from infection.

This dancer goes from being the emotional support for a previous patient to getting her own ingrown toenails permanently removed. Then, toenail trauma leads to fungus on multiple toes for a patient whose only course of action might be more drastic than he ever suspected. A little girl proves to be deceptively strong when she and The Toe Bro fight a stubborn wart. Lastly, The Toe Bro tackles severe ingrown toenails that prevent a patient from reaching full potential at the bowling alley.

After helping out at his dad's practice as a child, The Toe Bro found that he actually has a love for treating people with foot ailments. When a pair of quirky brothers come in, he uses that desire to help them with their ingrown toenails and calluses. He even gets some unexpected help removing a toenail. A drummer who wants to feel the beat of the drum without the pain of a wart enlists The Toe Bro to battle the mother of all warts. A BMX rider whose painful toes mean he can't ride with his sons calls on The Toe Bro to get him back in the saddle.

An Olympic swimmer takes home three new prizes after removing a fungal infection. Then a young man just wants to run and play, but his stubborn ingrown toenails are growing right through his flesh. A young woman needs to be able to deliver a roundhouse kick without pain, and so, after 25 years, she's looking to rid herself of her "gangster" toenails for good. Finally, a patient with a massive colony of 30 to 40 warts gets a much needed foot-lift.

One patient's decades-old fungal nails are so striking that she named them. Another had to sell his business because he literally can't stand his severely infected ingrown toenails. The Toe Bro ditches a one-year itch, and a daughter's juicy wart removal proves too much for her mother to handle.

The Toe Bro helps a patient kick her "nasty" feet to the curb so she can be a "fun" grandma again. The nurse becomes the patient as she says good-bye forever to her crazy-thick claw. An obsession with high heels causes a fashionista to walk the painful road to Ingrown City, and The Toe Bro breaks out the tech to help a lizard man cope with calluses that are painfully unnatural.